3-13-09_worms

3-13-09_worms - Zoology 470 2009 Course handouts Page 55...

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Zoology 470 – 2009 – Course handouts Page 55 Axis Specification and Gastrulation in C. elegans Introduction C. elegans is an excellent system for studying how individual cells become different in the eatly embryo because of its simplicity, reproducible cell lineage, and genetics. Having said that, the situation is still quite complex! We will restrict our discussion to cells that end up in the interior of the embryos, and which form two of the primary germ layers: MS, which forms mesoderm, including pharynx and muscle, and E, which forms the endoderm. These cells are daughters of a cell called EMS, which in turn is descended from the posterior cells at the two- cell stage, P1. Our goal is to identify molecular pathways that establish the fates of MS and E. The establishment of different blastomeres involves several steps: Step 1: The sperm entry point determines the posterior end of the zygote The sperm enters the oocyte at the future posterior end of the zygote. The sperm astral microtubules are thought to organize the cytoskeleton of the zygote, resulting in an initial
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This note was uploaded on 10/19/2009 for the course ZOO 470 taught by Professor Hardin during the Spring '08 term at Wisconsin.

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3-13-09_worms - Zoology 470 2009 Course handouts Page 55...

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