Study_Guide_for_Chapter_28 - BMB 402H STUDY GUIDE Spring...

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BMB 402H STUDY GUIDE Spring 2009 Chapter 28 Nucleotides 1. Chemical structures and nomenclature of bases, nucleosides, and nucleotides; numbering conventions for the ring atoms 2. Keto and enol forms of guanine and thymine; amino and imino forms of adenine and cytosine 3. The ring nitrogens of adenine, guanine, uracil and thymine that become protonated or deprotonated at extreme pHs 4. de novo purine biosynthesis from the synthesis of PRPP to the synthesis of IMP; chemical structures of the intermediates (no need to memorize their names) and types of reactions (except for the first two reactions, there is no need to memorize the names of the enzymes involved) 5. Synthesis of AMP and GMP from IMP; chemical structures and names of the intermediates; types of reactions and names of the enzymes involved 6. Reaction mechanism for the replacement of a carbonyl oxygen by an amino group; all the reactions (including one in the urea cycle) that utilize this mechanism 7. Regulation of de novo purine biosynthesis
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This note was uploaded on 10/19/2009 for the course B M B 402H taught by Professor Kao during the Spring '09 term at Pennsylvania State University, University Park.

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