Study_Guide_for_Chapter_25_I_

Study_Guide_for_Chapter_25_I_ - BMB 402H STUDY GUIDE Spring...

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BMB 402H STUDY GUIDE Spring 2009 Chapter 25 Lipid Metabolism (I) 1. Major classes of biological lipids 2. General chemical structure of triacylglycerols 3. Overview of fatty acid degradation 4. Fate of dietary triacylglycerols (TGs); enzymes involved in processing TGs, roles of bile salts and chylomicrons; how lipoprotein lipase is activated 5. The pathway for β -oxidation of saturated fatty acids; names of the enzymes, structures of the intermediates and final products; fate of electrons removed 6. Be familiar with mechanisms of fatty acyl-CoA synthetase and β -ketoacyl-CoA thiolase 7. Overall reaction of one cycle of β -oxidation of a saturated fatty acid with n carbons 8. How to calculate energy yield from β -oxidation of saturated fatty acids 9. Chemical similarity between the first three steps of β -oxidation and three TCA cycle reactions (which three?) 10. Advantages of β -oxidation of fatty acids over oxidation of glucose 11. The steps in conversion of propionyl-CoA to succinyl-CoA; the chemical nature of each of the reactions (i.e., carboxylation, etc.); be familiar with the role of co-enzyme 5’-adenosyl- cobalamin in the mutase reaction (there is no need to memorize its chemical structure) 12. β- oxidation of mono- and poly-unsaturated fatty acids; the additional enzymes required and
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Study_Guide_for_Chapter_25_I_ - BMB 402H STUDY GUIDE Spring...

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