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Study_Guide_for_Chapter_18 - BMB 402H STUDY GUIDE Spring...

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BMB 402H STUDY GUIDE Spring 2009 Chapter 18: Glycogen Metabolism 1. Chemical structures of glycogen and starch; linkage between glucose units; reducing end and non-reducing end 2. The enzymes involved in degradation of glycogen and the reactions they carry out; mechanism of phosphoglucomutase; why debranching enzyme is required 3. The enzymes involved in glycogen synthesis and the reactions they carry out; the dual roles of glycogenin 4. Compare glycosidic bond formation during the synthesis of lactose with that during glycogen synthesis 5. Physiological importance of branching in starch and glycogen 6. Different physiological functions of liver and muscle glycogen reserves 7. Compare liver phosphorylase and muscle phosphorylase in terms of how they are allosterically and hormonally regulated: what are the similarities and differences and what is the physiological rationale behind the differences? 8. Regulation of glycogen metabolism in muscle by epinephrine; pay attention to how
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