2009_Practice_Final_Exam - 1 BMB 402H SPRING 2009 Practice...

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BMB 402H SPRING 2009 Practice Final Exam NAME: _________________________________________________________ There are 29 questions on this exam worth a total of 120 points. Write your answer to each question in the space provided. If more space is needed, you may continue on the reverse side of the page; be sure to clearly indicate the question number. Write legibly to make grading easier. For all multiple-choice questions, circle the letter in front of each answer choice that you think is correct; one point will be deducted for each incorrect answer choice you choose. 1. Which of the following reactions employ(s) a similar mechanism as that of the argininosuccinate synthetase reaction in the urea cycle? (4 points) (a) the reaction converting IMP to adenylosuccinate (b) the reaction converting dCMP to dUMP (c) the reaction converting dUMP to dTMP (d) the reaction converting UTP to CTP (e) the reaction converting XMP to GMP (f) the reaction that closes the imidazole ring in de novo purine biosynthesis (g) the reaction converting AMP to IMP (h) the reaction converting dUTP to dUMP 2. Name one enzyme, or describe one reaction, that is inhibited by each of the following compounds. (5 points) (a) hydroxyurea _______________________________________________________ (b) azaserine _______________________________________________________ (c) 5-fluorouracil _______________________________________________________ (e) sulfonamide _______________________________________________________ (f) methotrexate _______________________________________________________ 3. During pyrimidine catabolism, the final breakdown product of cytosine is: _____________________. (1 point) 1
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4. The following three questions pertain to how birds incorporate the nitrogen atoms removed from excess amino acids into uric acid for excretion. (a). Use chemical structures to show a balanced reaction for the conversion of asparagine to aspartate, and name the enzyme involved. (3 points) (b). Use chemical structures to show the reaction that incorporates aspartate directly into an intermediate in de novo purine biosynthesis. Be sure to use chemical names or abbreviations to indicate any additional substrates and products in this reaction. (3 points) (c). Draw the chemical structure of uric acid and indicate on the structure the nitrogen that is directly contributed by aspartate. (2 points) 5. In rare cases of PKU, the metabolic defect lies in dihydropteridine reductase. What diet regimen would you recommend for these patients? Briefly explain your answer. (4 points) 2
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6. Draw the chemical structure of deoxythymidine monophosphate at pH 7, and name the compound that directly contributes to each of the atoms (or group of atoms) during the synthesis of this nucleotide. (4 points)
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This note was uploaded on 10/19/2009 for the course B M B 402H taught by Professor Kao during the Spring '09 term at Pennsylvania State University, University Park.

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2009_Practice_Final_Exam - 1 BMB 402H SPRING 2009 Practice...

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