2009_Practice_Exam_II - 1 BMB 402H Spring 2009 Practice...

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BMB 402H Spring 2009 Practice Exam II NAME: _________________________________________________________ There are 23 questions on this exam worth a total of 100 points. Write your answer to each question in the space provided. If more space is needed, you may continue on the reverse side of the page; be sure to clearly indicate the question number. Write legibly to make grading easier. For all multiple-choice questions, one point will be deducted for each incorrect answer. 1. Briefly describe how the activity of thermogenin is regulated, and explain why this regulation makes physiological sense. (4 points) 2. The chemical structure of CoQ (or ubiquinone) consists of a benzoquinone ring and a “tail”; however, only the benzoquinone ring is involved in redox reactions. What is the chemical structure of the tail (you may either draw the structure or simply describe the chemical nature of the structure), and what is its function? (3 points) 1
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3. A phophatidylserine molecule has a 16-carbon saturated fatty acyl chain attached to C1 and a polyunsaturated 16-carbon fatty acyl chain, with two double bonds, attached to C2. First, draw the chemical structure of this molecule, then indicate on the structure the chemical bond that will be cleaved by phospholipase D, and lastly provide the chemical names of the two cleavage products. (4 points) 4. The following statements about LDL/LDL receptor may or may not be true. Circle the answer choice(s) for the statement(s) that you think is (are) TRUE. (4 points) (a). LDL receptor is degraded in the lysosome after it has transported LDL to the lysosome. (b). LDL contains a higher percentage of cholesterol ester by weight than does VLDL. (c). The statin drugs (e.g., Zocor and Lipitor) currently used by patients with high blood cholesterol levels directly activate the transcription of the gene encoding the LDL receptor, thereby allowing the cell to bring in more serum LDL and IDL. (d). LDL is synthesized in the liver and secreted into the plasma. (e). LDL is the major carrier of triacylglycerols from the liver to non-hepatic tissues. (f).
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2009_Practice_Exam_II - 1 BMB 402H Spring 2009 Practice...

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