Class_2_highlights

Class_2_highlights - Highlights: Lecture 2 Describe the...

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Highlights: Lecture 2 Describe the "fluid mosaic model". What is a leaflet? Do phospholipids . .. diffuse in the plane of the bilayer? flip-flop between bilayers? Do integral membrane proteins. .. diffuse in the plane of the bilayer? (always? sometimes? never?) flip-flop between bilayers? Why do phospholipids spontaneously form liposomes when placed in a polar solvent such as water? Another way to ask this question is "what is a liposome?" Major membrane lipid components are phosphatidylserine phosphatidylcholine phosphatidylethanolamine sphingomyelin Less abundant components are cholesterol - why can cholesterol "flip-flop" while phospholipids can't? inositol phospholipids Where is most of the cellular cholesterol found? plasma membrane. What effect does it have on the membrane? thicker and less permeable How is the effect of cholesterol on membranes used to target proteins to different organelles? Clue: most ER proteins have shorter, about 18 amino acids, transmembrane domains, and plasma membrane proteins have longer, about 25 amino acids,
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Class_2_highlights - Highlights: Lecture 2 Describe the...

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