Class_5_highlights Kutay et al

Class_5_highlights Kutay et al - Kutay et al Be able to...

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Kutay et al Be able to describe a cycle of nuclear protein import including how is the RanGTP gradient generated? how are alpha and beta re-exported? what is the role of alpha during import? what is the role of beta during import? what is Rcc1? What is RanGAP? What is RanBP1? which factors actually bind RanGTP? (CAS and beta) Which complexes fall apart when Ran cleaves GTP to GDP? (the CAS/alpha/Ran complex and the beta/Ran complex) Which complexes actually form when RanGDP is present? (alpha/ beta complex - although note that RanGDP isn't in that complex) what is the role of CAS? What conditions (i.e., think about the state of Ran) allow CAS to bind importin alpha? what conditions allow importin beta to bind importin alpha? (yes, that's the same question as above just asked in a different way!) Note : this is a repeat from the previous lecture but you NEED TO KNOW how small GTP proteins switch between states! RanGTP becomes RanGDP by CLEAVING or removing a phosphate group from the GTP to form GDP, and RanGDP becomes RanGTP by releasing the GDP and binding a different molecule of GTP.
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