Intro_cell_signal_post09 - Signaling pathway - Chapter 15...

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I. The signaling molecule (a.k.a.: "ligand") II. The sensor / receptor III. The signal is transduced and amplifed through intracellular mediators common For a signal transduction pathway to involve chains or "cascades" oF kinases and phosphatases. V. The eFFector e.g., alteration oF the activity oF an ion channel, an enzyme, or a transcription Factor Signaling pathway - Chapter 15 in MBoC key For multicellular liFe development cancer pharmaceuticals
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1. Lipophilic hormones - considered the paradigm for a membrane permeable signal. I. Signaling molecules A. Plasma membrane permeable 2. Dissolved gases e.g., Nitric Oxide (NO) - causes blood vessel dilation •steroids, like estrogen, and other small hydrophobic molecules - (MBOC 15-12). •Many are derivatives of cholesterol. •Hormones bind speciFc members of the steroid receptor superfamily
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1. Soluble or membrane-bound (MBOC 15-5) proteins serve as signaling molecules. I. Signaling molecules B. Plasma membrane impermeable Margolis et a.l (1989) EGF induces tyrosine phosphorylation of phopholipase C-II: A potential mechanism for EGF receptor signaling. Cell 57:1101-1107. Olivier et al. (1993) A Drosophila SH2-SH3 adapter protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras Guanine Nucleotide Exchange, Sos. Cell 73:179-191. •Soluble - EGF •secreted and affects cell proliferation. •Membrane bound - Boss •In ±y eye, Boss (related to EGF) is a transmembrane protein in the R8 photoreceptor that binds a transmembrane receptor (sevenless) on a neighboring cell causing the neighbor to differentiate into the R7 photoreceptor. •we’ll be looking at 2 papers that focus on events downstream of EGF or Boss
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B. Plasma membrane impermeable 2. Many non-proteinaceous signals act in neurotransmission. Acetycholine (Ach) is a non-protein neurotransmitter involved in altering ion
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This note was uploaded on 10/19/2009 for the course B M B 460 taught by Professor Hanna-rose,w during the Spring '08 term at Pennsylvania State University, University Park.

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Intro_cell_signal_post09 - Signaling pathway - Chapter 15...

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