Olivier_et_al_guide - Guide for Olivier et al. (1993) A...

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Guide for Olivier et al. (1993) A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras Guanine Nucleotide Exchange, Sos. Cell 73: 179-191. These questions are intended to help you read the paper in an inquisitive fashion and to help you focus on some of the issues you should understand. Please cover each of these questions during your reading and studying. Please submit the answers to 5 of these questions for your homework assignment. 1) The paper focuses on delineating a signal transduction pathway that goes between the receptor tyrosine kinase and the GTP binding protein called Ras. This type of signal transduction pathway plays a major role in the development of the Drosophila eye. We already looked at another pathway where a receptor tyrosine kinase, EGFR, phosphorylates phospholipase C gamma which in turn leads to the production of the second messengers IP3 and diacylglycerol. Many of the proteins that interact with active receptor tyrosine kinases,
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This note was uploaded on 10/19/2009 for the course B M B 460 taught by Professor Hanna-rose,w during the Spring '08 term at Pennsylvania State University, University Park.

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