Highlights from class 11- Logothetis paper

Highlights from class 11- Logothetis paper - Lecture 11...

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Lecture 11/ Logothetis paper Highlights Describe on the molecular level why acetylcholine produces opposite effects in skeletal muscle and the sinoatrial node. e.g., difference in receptors o difference in ion channels o how membrane polarization is affected in opposite ways Know whether [Na+] and [K+] are higher inside or outside the cell, what drives them to move across the membrane when a channel is opened, and what the effect on the membrane potential is. How does rendering the membrane permeable to Na+ or K+ (i.e., opening of a Na+ or K+ channel) contribute to formation of an action potential? Compare what the authors set out to test versus what they discovered. o Does beta/gamma inhibit or activate K+ channel? o Why does the alpha subunit inhibit the ability of the beta gamma subunit to open K+ channels? Why do they need to use the inside out patch? What does this allow them to manipulate? Why couldn’t they permeabilize the membrane with detergent to add
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Highlights from class 11- Logothetis paper - Lecture 11...

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