Lee guide - Guide for Lee & Nurse. (1987) Complementation...

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the fission yeast cell cycle control gene cdc2. Nature 327, 31-35 These questions are intended to help you read the paper in an inquisitive fashion and to help you focus on some of the issues you should understand. Please cover each of these questions during your reading and studying. Please submit the answers to 5 of these questions for your homework assignment. 1) What is the normal function of the cdc2 gene in the fission yeast S. pombe? 2) What is the phenotype of temperature sensitive, loss-of-function mutations in cdc2 at the restrictive temperature? What is the phenotype of gain-of-function (dominant) mutations in cdc2? 3) The authors introduce a human cDNA library into a strain of yeast carrying a temperature sensitive mutation in the yeast cdc2 gene. Explain why a temperature sensitive mutation must be used. 4)
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This note was uploaded on 10/19/2009 for the course B M B 460 taught by Professor Hanna-rose,w during the Spring '08 term at Pennsylvania State University, University Park.

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Lee guide - Guide for Lee & Nurse. (1987) Complementation...

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