Terada_guide - Guide for Terada et al(2002 Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion Nature 416 542-545 These

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Guide for Terada et al. (2002) Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416: 542-545. These questions are intended to help you read the paper in an inquisitive fashion and to help you focus on some of the issues you should understand. Please cover each of these questions during your reading and studying. Please submit the answers to 5 of these questions for your homework assignment. 1. What is transdifferentiation? 2. What was the primary hypothesis that was being investigated regarding the effect that ES cells might have on an adult stem cell? 3. The authors are mixing two types of cells and want to be able to isolate the adult- derived stem cells after a period of co-culture. What property of the two cell types will allow them to isolate the bone marrow cells when desired? A related but seaparate question is how are the bone marrow cells “marked” to allow positive identification of bone marrow-derived cells? 4.
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This note was uploaded on 10/19/2009 for the course B M B 460 taught by Professor Hanna-rose,w during the Spring '08 term at Pennsylvania State University, University Park.

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Terada_guide - Guide for Terada et al(2002 Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion Nature 416 542-545 These

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