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Week%209-21 - This week office hour Wed 9/23 5:00-6:00 pm...

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This week office hour: Wed 9/23 5:00-6:00 pm Thur 9/24 5:00-6:00 pm RRI 3rd FL breakroom (across from 301)
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Fewer or more than one centromere is highly detrimental
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Differences in centromeres of eukaryotes
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The eukaryotic mitotic cell cycle During the Gap phases (G1 and G2) checkpoints ensure that all is well with the DNA and segregation machinery, before allowing DNA replication (S phase) and mitosis (M) to commence.
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Various levels of chromatin compaction during cell cycle
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Chromosome Cohesion and Condensation by SMC Proteins SMC proteins: the S tructural M aintenance of C hromosomes proteins
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S Phase Individual replication origins initiate replication and produce two replication forks per origin. During replication cohesin proteins assemble around the new DNA molecules, holding them together (cohesion). The fully replicated DNA molecules are called sister chromatids .
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M Phase Sister chromatids separate by the end of M pahse.
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Mitosis Sister chromatids are segregated to daughter cells. Checkpoints regulate various steps, especially the metaphase to anaphase transition to ensure accuracy.
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Meiosis After DNA replication, but before chromosome segregation, homologous (maternal and paternal) chromosomes pair and recombine .
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