Unformatted text preview: clonal expansion (proliferation) of pre-existing differentiated cells. 6. The neurons and Schwann cells (glia) isolated by FACS were confirmed to be greater than 95% pure populations. 7. Both Schwann cells and neurons were capable of inducing EphrinB2 expression in undifferentiated ECs when co-cultured for 2 days. 8. Again, as in #5 above, this represents as true induction, not an increase in EC number. 9. VEGF protein is the inducing molecule released by Schwann cells and neurons, and its acts specifically on undifferentiated ECS through VEGF-specific receptors (VEGF-R) on the surface of these cells. You should be able to describe the observations and/or experimental evidence that tend to support each of the above statements....
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- Spring '08
- cell biology, Cellular differentiation, Schwann Cell, sensory nerves, Glial cell