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bis_104_pq_20_fall_08 - that endothelial cells themselves...

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BIS 104 PQ 20 fall 08 20. In Figure 5, the data indicate that in the absence of Schwann cells (erbB3 mutant mice), arterial endothelial cells fail to differentiate. Based on these results, the authors conclude that Schwann cells are necessary for arteriogenesis. An alternative explanation for the failure of arterial cells to differentiate in erbB3 mutant mice is
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Unformatted text preview: that endothelial cells themselves require autonomous expression of the normal erbB3 gene in order to differentiate into arterial cells. How did the authors attempt to discriminate between these two possibilities?...
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