bis_104_midterm_ii_08

bis_104_midterm_ii_08 - Page 1 Name The diagram depicts a...

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Page 1 Name _____________________________ The diagram depicts a model for arteriogenesis in the embryonic limb skin. Peripheral sensory nerves (PSNs) 1 and/or associated Schwann cells 2 synthesize and secrete VEGF protein 3 . VEGF acts on undifferentiated (PECAM-1-positive; ephrinB2-negative) endothelial cells (ECs) 4 , some of which have transmembrane receptors for VEGF 5 . In response to binding VEGF, approx. 60% of the ECs begin to express ephrinB2 6 as they differentiate into arteries 7 . As the arterial vessels mature, smooth muscle cells (SMCs) 8 begin to associate with the vessel wall. You hypothesize that VEGF receptors in undifferentiated ECs are randomly distributed in the PM and are relatively free to move laterally in the membrane. However, once they bind VEGF, the receptors tend to cluster into discrete islands and lose their lateral mobility. 1. Describe two different cellular mechanisms that could cause the loss of mobility in these receptor/ligand complexes. (4) a) b)
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Page 3 Name ______________________________ 3. In order to characterize the plasma membrane proteins in the undifferentiated ECs, a pure (enriched) population of viable ECs was obtained.
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