bis_104_cell_cycle_fall_08

bis_104_cell_cycle_fall_08 - BIS 104 CONTROL OF CELL CYCLE...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
CONTROL OF CELL CYCLE A. Regulation of cyclin-dependent kinases (Cdks), the engines that drive the cell cycle. 1. Cyclin protein concentration Different cyclin genes are expressed at different times during the cycle. There are S-phase cyclins and M-phase cyclins (figs 14.5 and 14.8) 2. Cdk phosphorylation state Binding of cyclin to kinase is required but not sufficient to activate the kinase Threonine-161 on kinase is phosphorylated by Cdk-activating kinase (CAK) Tyrosine-15 on kinase is phosphorylated by wee-1 Complexes are now inactive (fig. 14.6) Phosphatase cdc-25 removes phosphate from tyrosine-15 to activate the complex 3. Cdk inhibitors 6 – 10 different proteins have been identified that bind directly to Cdk / cyclin complexes to inactivate (e.g., proteins p21 and p27). These are the “brakes’ on the engine and they prevent inappropriate entry into S-phase if DNA is damaged. 4.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/20/2009 for the course BIS 104 taught by Professor Scholey during the Winter '08 term at UC Davis.

Page1 / 4

bis_104_cell_cycle_fall_08 - BIS 104 CONTROL OF CELL CYCLE...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online