Unformatted text preview: Ca ++ channel opens. 4. Ca ++ influx triggers fusion of insulin containing vesicle with Beta cell PM. 5. Insulin enters blood stream and interacts with any cells that have insulin receptors on PM. 6. Insulin binds to receptor ( RTK: receptor tyrosine kinase) e.g., on adipocytes and initiates signal cascade that causes activation of protein kinase B ( PKB). 7. PKB mobilizes stored GLUT – 4 uniporter to the PM and glucose uptake is facilitated. Glyconeogenesis increases Glycolysis decreases Amino acid uptake and protein synthesis increase...
View Full Document
- Winter '08
- Amino Acids, blood glucose, elevated blood glucose, Insulin synthesis