b2_pka - RobertHua&AksiniyaAsenova BIS102HW2...

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BIS102 HW2
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Acid dissociation constant‐Ka Ka measures the strength of the acid in a solution. Commonly used in practice is pKa which is a logarithmic measure of the acid dissociation constant. pKa= ‐log 10 Ka Weak acids have large pKa values. Strong acids have small pKa values. The smaller the value of pKa the larger the extent of dissociation of the acid.
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Basic Amino Acids In living organisms enzymes kinetics are dependent on the pKa of the side chains of certain amino acids. The active site of the enzyme lumazine synthase contains basic amino acids. Basic amino acids have side chains with positive charges at neutral pH. As a result they can participate in electrostatic interactions in proteins.
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Occur between oppositely charged atoms or molecules. Charged residues are usually located on the protein surface. These interactions are very important for
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This note was uploaded on 10/20/2009 for the course BIS 102 taught by Professor Hilt during the Summer '08 term at UC Davis.

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b2_pka - RobertHua&AksiniyaAsenova BIS102HW2...

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