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BIS103_09MT2b Key_-1

BIS103_09MT2b Key_-1 - BIS103-002(Spring 2009 Midterm#2(May...

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BIS103-002 (Spring 2009) Midterm #2 (May 19) Name_____________________________________ 1 Instructor: Abel Student ID # ANSWER KEY Pls., check appropriate box below. This exam consists of 6 questions. A maximum of 100 points can be earned. Partial credit will be given. There are a total of 14 pages, including the cover page and one blank sheet at the end for notes. However, do not use the blank sheet for your final answers. If you need more space, use the back of pages 2-13. Write your name on top of each page! Petitions for re-grading will be considered only if you have used permanent ink , unless an addition error has occurred. *IT IS YOUR RESPONSIBILITY TO WRITE LEGIBLE! No extra effort will be made to decipher your handwriting. T = 25 o C (298 K) T = 37 o C (310 K) R = 8.315 J mol -1 K -1 F = 96.5 kJ mol -1 V -1 n = equivalents of electrons Z = charge of proton ! G o’ = – RTlnK eq ! G = ! G o ’ + RTln[Prod.]/[React.] ! G = ! G o ’ + 2.303RT ! pH ! G o’ = – nF ! E o’ ! E o’ = E o’ Oxidant – E o’ Reductant I,_______________________________________, authorize the University to distribute publicly this graded exam (e.g., handed out in class or left in a bin for pick up). I am aware of the fact that violations of the Academic Code of Conduct 1 may be reported to UC Davis Student Judicial Affairs. 1 Examples of academic misconduct include: receiving or providing unauthorized assistance on examinations, using unauthorized materials during an examination, altering an exam and submitting it for re-grading, or using false excuses to obtain extensions of time ( http://sja.ucdavis.edu/cac.htm ). Signature________________________________________ Date____________________________ Undergraduate Student Completing Incomplete Open Enrollment Student Graduate Student Question Value Score 1 16 2 25 3 20 4 11 5 10 6 18 + 2 TOTAL 100 (+2)
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BIS103-002 (Spring 2009) Midterm #2 (May 19) Name_____________________________________ 2 1. (16 pts) Questions related to the Tricarboxylic Acid (TCA) or Citric Acid cycle. a) Draw the structure of # -ketoglutarate into the box. (2 pts) b) The enzyme that uses # -ketoglutarate as a substrate in the TCA cycle, # -ketoglutarate dehydrogenase , has a requirement for two soluble and three tightly or covalently bound co-factors. Name these five co-factors. (5 pts) _____ Coenzyme A ________________________ _____ NAD + _____________________________ ________ FAD _________________________ _____ Thiamine pyrophosphate (TPP) _________ ______ Lipoic acid ____________________ c) The # -ketoglutarate dehydrogenase -catalyzed reaction releases carbon dioxide. Which carbon of # - ketoglutarate is converted to CO 2 ? Circle the carbon in the box above. (1 pt) d) The # -ketoglutarate dehydrogenase -catalyzed reaction is highly regulated by the availability of ATP and NADH. Briefly answer the following related questions: Explain why # -ketoglutarate dehydrogenase is a good target for regulation. (2 pts) The reaction catalyzed by # -ketoglutarate dehydrogenase is essentially irreversible (large negative ! G and loss of CO 2 ). Predict the effect (activation or inhibition) of ATP and NAD + (this is not a typo) on this enzyme. Circle. (2 pts) ATP : Activation Inhibition NAD + : Activation Inhibition
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BIS103-002 (Spring 2009) Midterm #2 (May 19) Name_____________________________________ 3 e) In addition to being an intermediate of the TCA cycle, # -ketoglutarate is also a building block for other compounds in metabolism, such as amino acids. If # -ketoglutarate is removed from the TCA
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