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Unformatted text preview: by the usual mechanism. During the work up with water, the aluminate salt is hydrolyzed to produce an equivalent of the carboxylic acid. Friedel-Crafts Syntheses with Cyclic Anhydrides Cyclic anhyrides are starting points for the multi-step synthesis of carboxylic acids. + succinic anhydride (i) AlCl 3 (ii) H 2 O CH 2 CH 2 C C O O O CCH 2 CH 2 COOH = O 3-benzoylpropanoic acid (88%) Zn(Hg), HCl reflux CH 2 CH 2 CH 2 COOH 4-phenylbutanoic acid (90%) CH 2 CH 2 C C O via AlCl 3 CH 2 C O: CH 2 C : :O AlCl 3-+ acylium ion O . . . . O . . . . O . . . ....
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- Organic chemistry, Carboxylic acid, Acetic anhydride, Acyl chloride, acid anhydride, Friedel-Crafts acylation reaction, acylium ion