Ch_322b_20.07

Ch_322b_20.07 - Some Biologically Important Amines The...

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Some Biologically Important Amines The amine function is widely found in biological systems. Two important structural types are described below. 2-Phenylethylamines (2-Phenylethanamines) CH 2 CH 2 NH 2 2-phenylethylamine Many compounds with this basic structure show powerful physiological and neurological effects. CHCH 2 NH CH 3 OH OH HO * adrenaline (epinephrine) (R)-(-) is natural product Adrenaline and noradrenaline ("nor" means missing a methyl group) are secreted by the adrenal gland and released into the bloodstream when animals sense danger. Adrenaline causes an increase in blood pressure and heart rate and prepares the body for quick action. CHCH 2 NH 2 OH OH HO * noradrenaline (norepinephrine) (R)-(-) is natural product Noradrenaline is a neurotransmitter also produced in the brain that causes an increase in blood pressure. When formed in excess, it causes a person to be elated or hyperactive. In large excess, noradrenaline induces a manic state while a deficiency induces depression.
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The Amphetamines and Related Structures Amphetamine (1-methyl-2-phenylethylamine) and closely related compounds have a powerful stimulating effect on the central
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This note was uploaded on 10/20/2009 for the course CHEM 322BL at USC.

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Ch_322b_20.07 - Some Biologically Important Amines The...

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