Ch_322b_20.14

Ch_322b_20.14 - The Sulfa Drugs: Sulfanilamide Chemotherapy...

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The Sulfa Drugs: Sulfanilamide Chemotherapy is the use of chemical agents to destroy infectious organisms without harming the host. Typically, chemotherapy is used to kill bacteria responsible for a disease. Early in the 20th century, Paul Ehrlich (Nobel Prize 1908) discovered the first therapeutic chemicals. As a medical student, Ehrlich observed that certain dyes stained tissues selectively. He reasoned that staining was the result of selective chemical reactions between the dyes and the biological materials. He began a search for dyes with selective affinities for microorganisms hoping to find dyes that would be selectively lethal to specific microorganisms that cause disease. ..his "magic bullet." Ehrlich discovered salvarsan as a treatment for syphilis in 1909. HO H 2 N As=As OH NH 2 salvarsan
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Discovery of Sulfanilamide Between 1909 and 1935, thousands of chemicals, including many dyes, were screened for activity. Very few "magic bullets" were found until a desperate father tried tried to save the life of his sick daughter in 1935. Gerhard Domagk
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This note was uploaded on 10/20/2009 for the course CHEM 322BL at USC.

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Ch_322b_20.14 - The Sulfa Drugs: Sulfanilamide Chemotherapy...

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