Vandenberg_Lec5_2009

Vandenberg_Lec5_2009 - Today: Reconstruction of the Action...

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1 Propagation of the Action Potential 10/9/09 Today: • Reconstruction of the Action Potential • Where are ion channels located? • Local signaling: Passive responses • Long distance signaling: Action Potentials Reconstruction of the Action Potential • Hodgkin & Huxley constructed a mathematical model of the Na and K conductances based on voltage-clamp recordings (received Nobel Prize in 1963) • Modeled the channels as being controlled by voltage-dependent “gates” • Used the channel properties to predict the action potential Na + channel model: • Activation gate “m”: rapidly opens in response to depolarization • Inactivation gate “h”: slowly closes in response to depolarization Current Time
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2 K + channel model: Activation gate “n”: slowly opens in response to depolarization Current Time Initiation of the Action Potential Feedback cycles of channel opening & closing are responsible for the action potential. • AP is self supporting, or regenerative Inactivate Na + channels Decrease Na + current Changes in Na and K conductances underlie the action potential: Depolarization: • Na channels open rapidly in response to depolarization. • Na conductance increases,
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Vandenberg_Lec5_2009 - Today: Reconstruction of the Action...

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