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05sept09 - NS 1150 Lecture 5 Sept 9th 09 Heart Burn o...

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NS 1150 Lecture 5: Sept 9 th , 09 - Heart Burn o Common symptom of older people. This is because the organs wear and the  sphincter loosens. Acid in the stomach is loosened.  o Nothing to do with heart.  o Gastroesophageal Reflux Disease (GERD) o Relatively common o Sympathetically mediated stress (usually related to stress, since stress is  sympathetic, and during this time the sphincter loosens whiles in stress.  o Treatment GERD Reduce the acidity with acid buffers Bicarbonate o Alka-seltzer: taken to neutralize the acids.  Acid blockers o Pepto Bismol  (bismuth: metal) block the cells from  producing acid.) o H2 Blockers (H2: histamine- neurotransmitter)  Tagamet, Zantac. Blocks the stimulants from  reaching the acid cells so stops the acid from  producing o Proton Pump inhibitors (PPI):  mechanism which is in the  cells in the lining of the stomach lining Prilosec, Provacid: blocks these pumps. Due to the drug, the acid producing cells increased  to fight the inhibitors, so when person stops using  the drug, it could cause  acid rebound.  Also  increases the chance of bacterial growth.  Body always tries to counter something that drives  the body to one side.  Avoiding foods and drugs that release gastrin (secretogogues) Sleeping vertically: acid will not leak out o Symptoms: all these drugs are geared at acid secretion which is the symptoms.  But the cause is stress for the lazy bowel.  Stomach Events - 1) “Cephalic” stage
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o Mucous Secretion (important) will covers the inside of stomach to protect it  against the acid.  - 2)  Gastrin : released into the blood stream within inner blood circulation when the  stomach starts to stretch. Stimulate acid producing cells. 
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