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19Oct16 - (regulation of body fat 2 Contribution a No...

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Lecture 18 NS 1150 Search for the physiological stimulus Stretching of the stomach relates to the signal that tells the body to stop eating. Removal of stomach does not kill a person. Central theories of eating Hypothalamus 1) Hypothalamus made up of nuclei (decides eating habits? When to stop eating?) 2) VMH: (feeding {satiating} center of the brain) a. Lesions cause: overeating and obesity. b. Stimulation causes: anorexia and wasting. 3) LH: a. Lesions cause: animals would not eat and lose weight even to the point of starving (anorexia and wasting) b. Stimulation causes: Overeating and obesity Gordon Kennedy 1) Hypothalmic Hyperphagia a. With lesion, the animal gets obese due to large food intake, but there is a point in time when it starts fading. (note) b. He said that there is no feeding center; but there is a Set-Point for body fat.
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Unformatted text preview: (regulation of body fat) 2) Contribution a. No feeding or satiety centers in brain b. Body (note) c. (note) 3) Critical component of Set-Point Theory a. There needs to be a way that adipose cell tells the brain how fat it is. b. (note) 1994 – zhang, proenca, Maffei, Baronne, Leopold, Friedman. Found Leptin 1) Note 2) Evidence against leptin a) Obese humans had more leptin than non-obese (unlike the rats) i) Leptin concentrations are proportional to body fat. b) Huge amount of variability in humans. c) Women have high leptin levels than men, but also high fat composition d) Contcentrations increase during pregnancy,, but intake does not decrease....
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