Lecture 9 Mutations, Genetic Drift and Flowbb

Lecture 9 Mutations, Genetic Drift and Flowbb - Mutations...

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Mutations
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Frameshift Mutation mRNA parental DNA amino acids altered mRNA DNA with base insertion altered amino- acid sequence arginine glycine tyrosine tryptophan asparagine arginine glycine leucine glutamate leucine
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Frameshift Mutation - Deletion Example: CCR5 Two allele types for Gene CCR5 + (normal allele) 32 (deletion mutant allele) Immune system: T cells
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32 / 32 strong protection + / 32 slow advance to AIDS + / + susceptible Genotype Phenotype
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Substitutions Original: The fat cat ate the wee rat. Mutation: The fat hat ate the wee rat
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Substitutions Silent: No change (redundancy) e.g. GAA & GAG = Glu Insign. Change Deleterious. Crucial change
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Sickle Cell Anemia
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Why does this deleterious mutation stay in the population?
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Heterozygote advantage
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Lethal diseases impart resistance to other diseases Cystic Fibrosis: Diabetes “Thrifty Gene”: Famine
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Random changes in allele freq. Loss in genetic variation
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This note was uploaded on 10/22/2009 for the course BIO 124 taught by Professor Griscom during the Spring '07 term at James Madison University.

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Lecture 9 Mutations, Genetic Drift and Flowbb - Mutations...

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