Vandenberg_Lec3_2009

Vandenberg_Lec3_2009 - NeuralSim Program: This week ONLY...

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1 NeuralSim Program: Discussion Section will meet in the Life Sciences Computer Facility 1805 or 1806 Psych East Wed morning section meets at 8:30- 9:30; all others at normal time. LSCF stickers are available from your TAs to use LSCF room 1804 during the weekdays (M-F 8:30am-6:00pm) Voltage-Dependent Membrane Permeability 10/5/09 Today: • Membrane Potentials: Use of the Nernst & Goldman Equations to understand how neurons signal • Membrane currents & the voltage clamp technique: What causes membrane permeability changes during the action potential? Action Potential • Elicited by depolarization • Threshold • All-or-nothing response • Fairly uniform amplitude
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2 Nernst Equation • Used to determine membrane potential when one ion is permeable Goldman Equation • Used to determine membrane potential when more than one ion is permeable P K [K] o + P Na [Na] o + P Cl [Cl] i P K [K] i + P Na [Na] i + P Cl [Cl] o V m = 58 log V m = E equil = 58 log [ion]
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Vandenberg_Lec3_2009 - NeuralSim Program: This week ONLY...

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