MCDB151_HW2

MCDB151_HW2 - MCDB 151/251 - HOMEWORK #2 Due Friday...

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MCDB 151/251 - HOMEWORK #2 Name___________________________ Section_____________ Due Friday 10/16/09 in Lecture Ion: Extracellular Concentration: Intracellular Concentration: K + 10 mM 120 mM 1) A cell containing only Na + channels and K + channels has the following intracellular and extracellular ionic composition: Na + 130 mM 20 mM Cl - 150 mM 120 mM a) What are the equilibrium potentials for K + , Na + , and Cl - ? (3 pts) b) At what potential will the Na current through open Na channels be zero? (1 pt) c) You perform voltage clamp experiments on this cell by holding the membrane potential at -90 mV, then the currents from the whole cell are recorded for voltage pulses to -20 mV, +20 mV and +60 mV (voltage pulses are indicated below). Draw the currents that you would expect from this cell. Label your currents corresponding to each of the voltage pulses (-20, +20 and +60 mV). (4 pts)
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d) The cell above is now treated with tetraethylammonium, and the experiment is repeated. For this TEA- treated cell, currents are measured for voltage pulses to -20, +20 and +60 mV. (1 pt each)
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MCDB151_HW2 - MCDB 151/251 - HOMEWORK #2 Due Friday...

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