MCDB101Bslideset9

MCDB101Bslideset9 - 321 Chpt 14(pg 489-508 Chromosomal Mutations Rearrangements changes in the order and/or location of genes on a chromosome

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1 Chpt 14 (pg. 489-508) - Chromosomal Mutations • Rearrangements – changes in the order and/or location of genes on a chromosome –Deletion –Duplication –Inversion –Translocation 321 Co In E Table 14.1 322 Co In E
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2 14.1 323 Comparing Mouse and Human Genomes 170 chromosomal event over 65 million years Co In E 14.2 324 Co In E
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3 Phenotypic Consequences of Deletions pseudodominance 325 Co In E Deletion Loops 326 Co In E
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4 Deletions can be used to locate genes Deletions to assign genes to bands on Drosophila polytene chromosomes Complementation tests crossing deletion mutants with mutant genes of interests Deletion heterozygote reveals chromosomal location of mutant gene Fig14.8 327 Co In E Duplications add material to the genome Fig. 14.11 329 Co In E
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5 Duplication loops form when chromosomes pair in duplication heterozygotes • In prophase I, the duplication loop can assume different configurations that maximize the pairing of related regions Fig. 14.11c 330 Co In E Duplications by unequal crossing over 14.13 331 Co In E
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6 Summary of duplication and deletion affects on phenotypes • Alter number of genes on a chromosome and may affect phenotype of heterozygote • Heterozygosity creates one or three gene copies and create imbalance in gene product altering phenotypes (some lethal) • Genes may be placed in new location that modifies its expression • Deletions and duplications drive evolution by generating families of tandemly repeated genes 332 Co In E Inversions reorganize the DNA sequence of a chromosome • Produced by half rotation of chromosomal regions after double-stranded break • Also rare crossover between related genes in opposite orientation or transposition Fig. 14.14a, b 333 Co In E
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7 An inversion can affect phenotype if it disrupts a gene Fig. 14.14c 334 Co In E Inversion heterozygotes reduce the number of recombinant progeny • Inversion loop in heterozygote forms tightest possible alignment of homologous regions Fig. 13.12 335 Fig 14.15 Co In E
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Gametes produced from pericentric and paracentric inversions are imbalanced
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This note was uploaded on 10/22/2009 for the course MCDB 101B taught by Professor Christofferson during the Summer '09 term at UCSB.

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MCDB101Bslideset9 - 321 Chpt 14(pg 489-508 Chromosomal Mutations Rearrangements changes in the order and/or location of genes on a chromosome

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