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Unformatted text preview: Dominant Negative Haploinsufficiency Ectopic expression Triplet repeat mutations: permutated versus disease alleles; Mechanism of triplet repeat expansion. Chapter 4 Primary Concepts Chromosomes, homologous versus nonhomologous Sister chromatids nonsister chromatids Centromere, p and q chromosome arms Karyotype Nondisjunction Meiosis reductional division versus equational division Prophase I = leptotene, zygotene, pachytene, diplotene, diakinesis Synaptonemal complex Cohesin in lateral elements Crossing over chiasmata Monopolin, separin, cohesin - distal to chiasmata versus centromeric Meiosis generates genetic diversity How? Sex determination heterogametic versus homogametic sex Pseudoautosomal Regions (PAR1 and PAR2) versus sex chromosome specific Sex Linkage: dominant versus recessive inheritance patterns Sex-linked genes in human pedigrees...
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This note was uploaded on 10/22/2009 for the course MCDB 101B taught by Professor Christofferson during the Summer '09 term at UCSB.
- Summer '09