MCDB_101B_Midterm_1_Study_Guide

MCDB_101B_Midterm_1_Study_Guide - Dominant Negative...

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MCDB 101B Midterm 1 Study Guide Chapter 2 Primary Concepts Gene Alleles Homozygous Heterozygous Genotype Phenotype Dominant Recessive P, F1, & F2 generations test cross True-breeding Law of Segregation Law of Independent Assortment Monohybrid 3:1, 1:1, 1:2:1 ratios Dihybrid 9:3:3:1, 1:1:1:1 ratios Pedigrees and probabilities Product rule versus sum rule of probability Chapter 3 Primary Concepts Codominant Incomplete dominance Multiple alleles Allelic series Lethal alleles Conditional alleles A Y is a recessive lethal allele but is dominant for coat color. What is the molecular mechanism? Pleiotropic Gene Interactions Four distinct phenotypes Complementary interactions Recessive Epistasis Dominant Epistasis Penetrance Expressivity Genetic Heterogeneity Chapter 7 & 8 Primary Concepts Dominant versus recessive alleles depends on how alleles determine phenotypes Null, hypermorphic, hypomorphic alleles, neomorphic
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Unformatted text preview: Dominant Negative Haploinsufficiency Ectopic expression Triplet repeat mutations: permutated versus disease alleles; Mechanism of triplet repeat expansion. Chapter 4 Primary Concepts Chromosomes, homologous versus nonhomologous Sister chromatids nonsister chromatids Centromere, p and q chromosome arms Karyotype Nondisjunction Meiosis reductional division versus equational division Prophase I = leptotene, zygotene, pachytene, diplotene, diakinesis Synaptonemal complex Cohesin in lateral elements Crossing over chiasmata Monopolin, separin, cohesin - distal to chiasmata versus centromeric Meiosis generates genetic diversity How? Sex determination heterogametic versus homogametic sex Pseudoautosomal Regions (PAR1 and PAR2) versus sex chromosome specific Sex Linkage: dominant versus recessive inheritance patterns Sex-linked genes in human pedigrees...
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This note was uploaded on 10/22/2009 for the course MCDB 101B taught by Professor Christofferson during the Summer '09 term at UCSB.

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