MCDB101Bslideset5

MCDB101Bslideset5 - 157 Linkage, Recombination, and the...

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1 • Linkage and meiotic recombination – Genes linked together on the same chromosome usually assort together – Linked genes may become separated through recombination • Mapping – The frequency with which genes become separated reflects the physical distance between them Linkage, Recombination, and the Mapping of Genes on Chromosomes (chpt 5) 157 Co In E Crossing over leads to separation of linked genes during meiosis A A a a B B b b Gametes a B A B A b a b x Parental Recombinant 158 Co In E
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2 Linkage at a sex-linked gene • Deviation from 1:1:1:1 ratio of phenotypes for males Fig. 5.2 159 Co In E Parental vs Recombinant classes are defined by the allele combinations in the gametes from the Parental generation Fig 5.3 160 Co In E
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3 Fig. 5.4 Linkage in Autosomal genes 161 Co In E Genetic recombination between car and Bar genes on the Drosophila X chromosome Fig. 5.7 162 Co In E
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Mapping Functions 163 Co In E Observed versus Predicted Outcomes • Transmission of gametes is based on chance events which are subject to random variation. • Chi square test measures “goodness of fit” between observed and expected (predicted) results • Chi square test is used in genetics to compare experimental data with the predicted outcomes based a genetic hypothesis. • Hypotheses can include no linkage (random assortment), gene interaction (recessive epistasis), etc. 164
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MCDB101Bslideset5 - 157 Linkage, Recombination, and the...

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