MCDB101Bslideset2

MCDB101Bslideset2 - 52 Chapter 3 - Extensions to Mendelian...

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1 Chapter 3 - Extensions to Mendelian Genetics • Beyond simple dominant and recessive interactions • Multiple Alleles • Gene Interaction – Multiple genes determining one phenotype 52 Co In E Dominance is not always complete 3.2 53 Co In E
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2 3.3 54 Co In E 3.4a 55 Co In E
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3 3.4b 56 Co In E 3.6 57 Dominance relationships in an allelic Series Co In E
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4 3.7 Agouti gene 58 Co In E 3.9 60 Co In E
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5 Why is A Y a recessive lethal? From: Development. 1994 Jun;120(6):1695-708. 61 Co In E Variations on monohybrid inheritance Mendelian Inheritance Variation on Mendelian Inheritance F2 Phenotypic Ratios Complete Dominance Incomplete dominance or codominance 1:2:1 instead of 3:1 Two alleles Multiple alleles series of 3:1 ratios All genotypes equally viable Recessive lethal alleles 2:1 One gene determines one trait Pleiotropy: one gene influences several traits Difference ratios depending on dominance relations for each trait 62 Co In E
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6 Pleiotropy of Sickle Cell 3.10 63 Co In E Two genes interacting to determine one phenotype: different biochemical pathways A B Reactant a Product A Reactant b Product B + = Dominant trait 64 Co In E
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7 3.11 65 Co In E Two interacting genes on the same biochemical pathway Complementary gene interaction - 9:7 Recessive epistasis - 9:3:4 A B Reactant a Product A Product B 66 Co In E
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8 3.13 67 Co In E 3.14a Recessive Epistasis: Coat Color in Labrador Retrievers 68 Co In E
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9 ii H– genotype Substance H A sugar B sugar No substance H AB phenotype O phenotype Bombay phenotype I A I B H –genotype (b) Molecular basis of the Bombay phenotype Genotype Phenotype hh genotype 3.14b 69 Co In E AA BB aa bb A B A B A B A b a B a b A b a B a b a b Aa Bb Aa Bb P Gametes
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This note was uploaded on 10/22/2009 for the course MCDB 101B taught by Professor Christofferson during the Summer '09 term at UCSB.

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MCDB101Bslideset2 - 52 Chapter 3 - Extensions to Mendelian...

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