Bio 305 Lecture 3: Sex-linked inheritance, pedigrees and proof of the chromosomal theory Jan 13, 2009 Dr. Long Required reading:Pre-lecture reading below, including specified book pages Optional further reading: Chapter 2 (p. 57-75) Relevant end of chapter problems: Chapter 2 (30, 37 - 52, 54, 56, 57) Relevant problems in the course pack: 6-11 Vocabulary: (also see genetic notation summary) affected individualautosome Bayes’ theorem carrier complement of an event conditional probability dimorphism haploid chromosome set (n) hemizygous heterogametic homogametic nondisjunction pedigree analysis ploidy polymorphism posterior probability prior probability sex chromosomes (X chromosome, Y chromosome) sex-linkage total probability law X-linkage Y-linkage Learning Goals: Based on the reading and lecture material from lecture 3, you need to be able to: 1.Describe the similarities and differences between human X and Y chromosomes as well as the evolutionary origin of the Y chromosome. 2.Draw the segregation of sex chromosomes during mitosis and meiosis. 3.Describe features of chromosome number, sex chromosomes and sex determination that are the same and different among species. 4.Explain how genes were first shown to be located on chromosomes. 5.Predict inheritance patterns for X-linked genes. 6.Use pedigree data to infer the most likely mode of inheritance for a trait and to predict the probability of additional offspring inheriting the trait. 7.Translate descriptions of phenotypes into appropriate genotypic notation in pedigrees and in standard crosses. 8.Compute posterior probabilities using Bayes' theorem. 9.Calculate conditional probabilities, when appropriate.Lecture 3 1
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