Bio 305 Lecture 13:
Introduction to Quantitative Genetics
Feb 19, 2009
Dr. Long
Required reading:
Pre-lecture reading below and Chapter 18.
Be sure to read 669-673.
Relevant end of chapter problems: Chapter 18 (1,2,5-8,14)
Course pack problems:
44-54
Vocabulary:
additive effect
average effect
candidate genes
correlation
genetic correlation
phenotypic correlation
covariance
familiality
genetic markers
genetic variance
heritability
broad sense heritability
narrow sense heritability
mean
mid parent value
norm of reaction
quantitative trait loci
selection differential
selection response
truncation selection
standard deviation
variance
phenotypic variance
additive genetic variance
dominance variance
environmental variance
Learning goals:
Based on the reading and lecture material from this lecture, you need to be able to:
1.
Describe quantitative traits using the mean and the variance.
2.
Use the correlation coefficient to measure the similarity of relatives.
3.
Calculate the average effect and additive effect of genes.
4.
Use the norm of reaction to characterize phenotypes as a response to genes and
environments.
5.
Partition genetic variance into components related to additive and dominance effects.
6.
Determine which traits will respond best to selection, based on their heritability.
7.
Determine the placement of a QTL relative to molecular markers given phenotypic
and genotypic information from a backcross.
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