Bio 305 Lecture 13: Introduction to Quantitative Genetics Feb 19, 2009 Dr. Long Required reading:Pre-lecture reading below and Chapter 18. Be sure to read 669-673. Relevant end of chapter problems: Chapter 18 (1,2,5-8,14) Course pack problems: 44-54 Vocabulary:additive effect average effect candidate genes correlation genetic correlation phenotypic correlation covariance familiality genetic markers genetic variance heritability broad sense heritability narrow sense heritability mean mid parent value norm of reaction quantitative trait loci selection differential selection response truncation selection standard deviation variance phenotypic variance additive genetic variance dominance variance environmental variance Learning goals:Based on the reading and lecture material from this lecture, you need to be able to: 1.Describe quantitative traits using the mean and the variance. 2.Use the correlation coefficient to measure the similarity of relatives. 3.Calculate the average effect and additive effect of genes. 4.Use the norm of reaction to characterize phenotypes as a response to genes and environments. 5.Partition genetic variance into components related to additive and dominance effects. 6.Determine which traits will respond best to selection, based on their heritability. 7.Determine the placement of a QTL relative to molecular markers given phenotypic and genotypic information from a backcross. 1
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