Lecture 13 - Lecture 13 Biosynthesis of C and N Compounds...

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1 Lecture 13 Read: BBOM 12e Sec. 5.16, 6.4, 20.14 Central Metabolites Biosynthesis of C and N Compounds Nitrogen metabolism Peptidoglycan Synthesis Central Metabolites There are 12 (or 13) central metabolites (intermediate compounds) from which the monomers of macromolecules are synthesized. fructose-6-PO4 ribose-5-PO4 erythrose-4-PO4 Polysaccharides glycogen, starch Deoxyribose & ribose for nucleic acids, Vitamins and cofactors Amino acids for proteins Glycerol for lipids Fatty acids for lipids Heme proteins From E.coli to elephants— Biosynthetic pathways are very similar!!! NAG, NAM for peptidoglycan LPS Sedoheptulose-7 PO4
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2 Peptidoglycan Synthesis BBOM 12e Fig.6.5 Three key enzymes in periplasm: Autolysin Glycosylase Transpeptidase More on Biosynthesis BBOM 12e Sec. 5.15-5.17 Sugars Æ polysaccharides Nucleotides Æ nucleic acids Fatty acids Æ lipids BBOM 12e Sec. 25.1, 25.2, 16.6 Antibiotics and other secondary metabolites of industrial importance BBOM 12e Chapter 7- DNA, RNA, and Protein Synthesis Lectures 20 - 22 BBOM 12e Sec 6.4 Peptidoglycan Synthesis
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This note was uploaded on 10/25/2009 for the course BIO 2900 taught by Professor Ghiorse during the Fall '07 term at Cornell University (Engineering School).

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Lecture 13 - Lecture 13 Biosynthesis of C and N Compounds...

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