HUN4446 liver 1 - CHO Metabolism: glycogen synthesis and...

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iver Blood Supply: portal vein: straight from GI tract 2/3 of liver blood supply very nutrient rich hepatic artery 1/3 of liver blood supply sinusoids (capillaries-oxygen exchange => central hepatic vein=> inferior vena cava General: essential for life 2 lobes hepatic ducts: bile drains from these Sphincter of Oddi: determines where bile goes Structure : hepatocytes: liver cells bile canaliculi Functions: blood volume regulation detoxification bile production metabolic functions Bile Emulsifying agent- decreases the surface tension and allows intestinal agitation to brak up fat  globules Absorption of fatty acids, monoglycerides, cholesterol and other lipids – micelle formation – soluble composed of: water, bile salts, bilirubin (waste product of hemoglobin breakdown), electrolytes Example of metabolic funtions
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Unformatted text preview: CHO Metabolism: glycogen synthesis and storage glycogenolysis monosaccharide conversion conversion of AA reidues Fat Metabolism: formation of lipoproteins fatty acid oxidation (occurs at high rate) cholesterol and phospholipid synthesis bile salt formation conversion of CHO and protein to fat Protein Metabolism: deamination of AA synthesis of plasma proteins synthesis of prothrombin/clotting factors urea formation transamination Other: storage of vitamins storage of minerals blood coagulation Liver function tests (LFTs) AST (SGOT) ALT (SGPT) Alkaline phosphatase Gamma glutamyl transpeptidase (GGT) Albumin Total bilirubin (breakdown product of Hgb) Indirect (unconjugated) Direct (conjugated)...
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HUN4446 liver 1 - CHO Metabolism: glycogen synthesis and...

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