Handouts for substituton and elimination reactions-1

Handouts for substituton and elimination reactions-1 -...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Nucleophilic Substitution Reactions Two Types: 1] S N 2 Reaction:Nucleophilic Substitution Reaction of the 2nd Order H H 3 C . H 2 C Br H 3 C NaOH Heat C H H 3 CH 2 C CH 3 Br HO Transition State OH CH 2 CH 3 H HO CH 3 Nucleophile (OH) approaches from opposite side of the leaving group(Br) "R" config "S" Config + - - Inversion of configuration from R to S Features of S N 2 reactions: 1) There is an inversion of stereochemistry at the reaction center. 2) Rate equation : R = k[Nucleophile][substrate] i.e. increase in concentration of any of the two will result in faster reactions. 3) The slow step and hence the rate determining step is the 1st step that leads to the formation of the transition state. 2nd step is very fast and hence not rate determining. 4) It is a 1 step reaction with no intermediate carbocation. 5) Nucleophiles can be negatively charged or neutral compounds. 6) Order of reactivity: Slow Step Fast C X H H H C X R H H C X R H R C X R R R Methyl Primary halide Secondary Tertiary
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/26/2009 for the course CEM 351 taught by Professor Rathke during the Spring '08 term at Michigan State University.

Page1 / 7

Handouts for substituton and elimination reactions-1 -...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online