Problem Set #3

Problem Set #3 - Biology 100 Problem Set#3 due 1 In...

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Biology 100 Problem Set #3 due: October 19, 2009 1. In mammalian skeletal muscle, myoglobin serves as O 2 repository. For sperm whale myoglobin, p 50 = 0.26 kPa O 2 . (a) In physiological terms, what does p 50 mean? In resting (aerobic) skeletal muscle, pO 2 ≈ 4 kPa. In physiologically active (contracting) skeletal muscle, pO 2 declines to ≈ 0.4 kPa in seconds. (b) Calculate myoglobin (O 2 ) values for both physiological conditions. (c) Calculate the difference in (O 2 ) values, (O 2 ), for these conditions. What does this (O 2 ) value signify in physiological terms? (d) In mammals, myoglobin is not found in more slowly metabolizing tissues, which are also oxidative ( i.e. , consume O 2 ). Why not? 2. As discussed in class, the modulator 2,3- bis -phosphoglycerate (2,3-BPG) regulates hemoglobin activity. (a) Does 2,3-BPG bind more strongly to T-state or R-state hemoglobin? Why? (b) In response to high altitude acclimation, after several days at 4500 m elevation, adult human erythrocytes typically increase 2,3-BPG levels from 5
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This note was uploaded on 10/27/2009 for the course BIO 100 taught by Professor Rothwell during the Fall '08 term at UCSC.

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Problem Set #3 - Biology 100 Problem Set#3 due 1 In...

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