lecture 11 transcription

lecture 11 transcription - Transcription the players-RNA...

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Transcription: the players -RNA polymerase -Promoter -Regulatory proteins--positive and negative regulators -Shine-Dalgarno sequence on transcript (translation)
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Transcription is the primary site of control in prokaryotes Prokaryotic genes are arranged in operons Promoters drive the expression of genes
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Coordinate Regulation Expression of several or numerous genes can be controlled simultaneously. Operon : a set of genes that are transcribed from the same promoter and controlled by the same regulatory sites. Regulon : a set of genes (and/or operons) expressed from separate promoter sites, but controlled by the same regulatory molecule. Global regulons may coordinate expression of many genes and operons, and may induce some, but repress others.
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Sigma factors control of regulons Sigma factors control of regulons Varied by synthesis of new Varied by synthesis of new σ σ subunits that cause subunits that cause RNA polymerase to recognize different promoter RNA polymerase to recognize different promoter sequences.
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