LecTitles+++09 - 11 10-29 translocations, rings; meiotic...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
HUMAN AND EUKARYOTIC GENETICS BIO D137 SH 134 code 05580 Proposed lecture schedule J.L. Marsh Fall 2009 Tu Th 9:30 - 10:50 Lecture Topic READ Chaps** 1 9-24 Background exam, course intro, course objectives, first day quiz 2 9-29 What do Genes do? Genes & biochemical basis of phenotype. Pathways, 1gene:1enz, dominance relationships, complementation (tyr metabolism). 7 3 10-1 Is it Genetic?: Mendel I, Twin studies, pedigree analysis, Ascertainment 3 4 10-6 Problems affecting ascertainment, penetrance, expressivity, epistasis, environment. 4 5 10-8 Sex linkage, segregation and disease Errors of segregation: meiotic/mitotic non-disjunction BB 8:177-194 6 10-13 Sex determination, mosaics & gynanders Assigning linkage 7 10-15 Recombination mapping, chiasma, crossing over Special problems in human gene mapping (LOD scores) 9 8 10-20 Human gene mapping continued: 9 10-22 Chromosome aberrations: deficiencies, duplications, 8:153-173 10 10-27 Chromosome aberrations: inversions, double minutes & HSRs
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 11 10-29 translocations, rings; meiotic and mitotic behavior 12 11-3 MID TERM EXAM Tuessday Nov 3 13 11-5 Molecular genetics: DNA & RNA, gene cloning, manipulating DNA, molecular identificaton of genes. The promise and perils of SNPs 2; 5 Nov 11 11-10 Structure & function of genes and genomes: Human globin genes: molecular nature of mutations and biochemical basis of phenotype 6; 7 14 11-12 DNA polymorphisms as markers or alleles: RFLPs, HVRs, ASOs & PCR. 5; 10 15 11-17 Applications to diagnostics, forensics, mapping etc 11 16 11-19 Genomic imprinting and non-Mendelian genetics 8:174 17 11-24 Forensics: Guest lecture -- 11-26 THANKSGIVING DAY 18 12-1 Genetics of Cancer: Predisposition, loss of heterozygosity, somatic mutations. 19 12-3 Review & discussion of social issues Final = Thu, Dec 10, 8:00-10:00am SH134 ** Chapter #s in bold refer to: Principles of Medical Genetics by Gelehrter. Collins, Ginsburg. These and other reference materials are on reserve...
View Full Document

Ask a homework question - tutors are online