PS2+09 - Bio D137 Human Eukaryotic Genetics th J.L Marsh...

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1 Bio D137 Human Eukaryotic Genetics J.L. Marsh F'09 PROBLEM SET #2 DUE Tues 10/6 by 4pm in the box, 5 th floor MH 1]. In the following pedigrees, assume that the disease trait is rare in the population. Answer the following questions about each pedigree: a] What is the probable mode of inheritance for family 1 and for family 2 ie. Dominant or recessive? Why? b] What are the possible genotypes of individuals X and Y in each pedigree? [1] [2] X Y X Y 2] People who suffer from autism are withdrawn and self-absorbed. In a study of 22 pairs of identical twins, both twins were autistic, and in all cases the parents were normal. With dizygotic twins where the pair was identified by finding an autistic child, in 10 of 42 pairs of twins, both twins were affected. What does this suggest about the mode of inheritance of autism? How do you explain frequency of concordance of the dizygotic twins? 3]. In studying the autosomal recessive disease, muscular dystrophy, a total of 106 families were identified by finding sibships with
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PS2+09 - Bio D137 Human Eukaryotic Genetics th J.L Marsh...

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