Bio_1A_Lecture_24_Development

Bio_1A_Lecture_24_Development - F e r t iliz a t io n a n d...

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Fertilization and Early Development Human embryo 6-8 wks
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Sperm-binding receptors Jelly coat Acrosome Actin Sperm head Contact Acrosomal reaction Acrosomal process Contact and fusion of sperm and egg membranes Entry of sperm nucleus Cortical reaction Fertilization envelope Egg plasma membrane Vitelline layer Hydrolytic enzymes Cortical granule Fused plasma membranes Perivitelline space Cortical granule membrane EGG CYTOPLASM Fertilization brings the haploid nuclei of sperm and egg together, forming a diploid zygote Sperm contact with the egg surface initiates metabolic reactions in the egg that trigger the onset of embryonic development. The acrosomal reaction is triggered when the sperm meets the egg. This reaction releases hydrolytic enzymes that digest material surrounding the egg fast block to polyspermy slow block to polyspermy
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Ca 2+ that stimulates cortical granule release. Point of sperm entry Spreading wave of calcium ions 1 sec before fertilization 10 sec after fertilization 20 sec 30 sec 10 sec after fert. 25 sec
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Bio_1A_Lecture_24_Development - F e r t iliz a t io n a n d...

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