Diana_Handout1_key_90809

Diana_Handout1_key_90809 - BIO 1A General Bio logy GSI...

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BIO 1A General Biology GSI: Diana Nguyen [email protected] OH: W 1-2, F 10-12 2084 VLSB 1 Handout #1 Co-translational vs post-translational import All polypeptides start their translation on a free ribosome and all ribosomes are the same. What differentiate different pathways is the first segment (the signal sequence at the N terminus ) which tells whether it stays in the cytosol, targeted to certain organelle (post-translational import), or attached to RER to continue its translation (co-translational import) 1. Post- translational import Proteins are fully formed by free ribosomes in the cytosol, then imported (happens AFTER translation: “post-translational”) to various organelles: Nucleus (Important) Never Mitochondrion Mail Peroxisome Poisonous Chloroplast Chemicals 2. Co- translational import Involves Signal Recognition Particle which takes protein and ribosome to ER As the protein is being made, it is being inserted into the lumen of the rough ER Path: RER lumen → Golgi Complex→ various destinations: Nuclear membrane Nike Lysosome Likes Secretion out of cell Sponsoring Vacuole Very ER Experienced Plasma membrane Players
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BIO 1A General Biology GSI: Diana Nguyen [email protected] OH: W 1-2, F 10-12 2084 VLSB 2 What happens after proteins are taken to the Endroplasmic Reticulum (ER)?
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