1 - 3) Ca++ ions trigger vesicles of Ach to fuse with the...

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Sheet1 Page 1 Lecture 15: Muscle Physiology Reading: chapter 8, section: skeletal muscle, pgs 253-259 (pgs 257-263, if using 5th edition) Types of Muscle (3 types) skeletal muscle & striated, voluntary cardiac muscle ± striated, involuntary smooth muscle ± unstriated, involuntary Skeletal Muscle & Neuromuscular Junction, sequence of events: 1) Action potential propagates into the presynaptic terminal 2) Depolarization of the presynaptic terminal opens voltage-gated Ca++ channels
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Unformatted text preview: 3) Ca++ ions trigger vesicles of Ach to fuse with the plasma membrane 4) ACh diffuses across the synaptic cleft and binds with receptors in the motor endplate 5) ACh binding with the receptor leads to the opening of cation channels. Na++ enters and depolarizes the end plate (EPP) 6) Depolarizing current flows to adjacent membrane that contains voltage-gated Na++ channels (action potential) 7) Ach is degraded by Ach-esterase, terminating the action of ACh...
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This note was uploaded on 10/29/2009 for the course NPB NPB 101 taught by Professor Weidner/wingfield during the Fall '08 term at UC Davis.

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