17 - 5 phosphorylated myosin binds to actin to form the...

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Sheet1 Page 1 Excitation-contraction coupling of smooth muscle (Figure 8-29,8-30) 1) self-excitation or neuronal excitation leads to Ca++ entry from the extracellular space through voltage-gated Ca++ channels 2) Ca++ entry triggers the internal release of more Ca++ from the sarcoplasmic reticulum 3) Ca++ binds with calmodulin, an intracellular protein similar to troponin 4) the Ca++-calmodulin complex activates myosin kinase which phosphorylates myosin
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Unformatted text preview: 5) phosphorylated myosin binds to actin to form the activated cross-bridges 6) removal of Ca++ leads to dephosphorylation of myosin and the dissociation of myosin from actin 7) gap-junctions enable excitation of one cell to propagate rapidly to all the coupled cells in a network 8) contraction strength is graded in proportion to the cytosolic Ca++ concentration...
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This note was uploaded on 10/29/2009 for the course NPB NPB 101 taught by Professor Weidner/wingfield during the Fall '08 term at UC Davis.

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