CC.SIADH copy.docx - Syndrome of Inappropriate Antidiuretic...

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Syndrome of Inappropriate Antidiuretic Hormone (SIADH)Pathophysiology: SIADH is a problem in which vasopressin (ADH) is secreted even when plasma osmolarity is low or normal (usually normal or low plasma levels inhibit ADH production and secretion). So, when ADH continues to be released this leads to disturbances in the fluid and electrolyte balance.Water is retained, resulting indilutionalhyponatremia and fluid overload. The increase in blood volume increases kidney function and inhibits the release of renin and aldosterone, which increases urine sodium loss- leading to worsening hyponatremia.Causes: Malignancies (Cancers)Small cell lung cancerPancreatic, duodenal and GU carcinomasHodgkin’s and Non- Hodgkin’s lymphomaPulmonary DisordersViral and bacterial pneumonia Lung abscessesActive tuberculosis PneumothoraxChronic Lung DiseasesMy costsPositive pressure ventilation (PEEP) Clinical manifestations related to symptoms ofhyponatremia

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