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041409homework - dementia of the Alzheimer's type Explain...

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Homework due 4/14/09 Name ______________________________ 1. What is the function of the APP gene? Why do we think this? Why must the APP protein be continuously replaced? How is this normally accomplished? 2. How is the APP protein disposed of, if the neuron makes too much of it or if it is misfolded inside the storage vesicle? Explain. 3. Mutations in what three genes predispose to early-onset Alzheimer's Disease? Why do these mutations cause problems? Why do Down Syndrome patients develop early-onset Alzheimer's Disease? 4. Mutations in what 2 genes predispose to late-onset Alzheimer's Disease (Senile
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Unformatted text preview: dementia of the Alzheimer's type). Explain this the events that lead to this predisposition 5. Describe the two recently discovered additional mechanisms by which β-amyloid and presenilin proteins are thought to contribute to the development of Alzheimers 6. Describe various treatments for Alzheimer's (both real and proposed) and explain their likely mechanism of their therapeutic actions. 7. Why are all the current treatments for Alzheimers Disease best described as “bandaids”?...
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