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041409SAHomework - Homework due Name Nestler E J R C...

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Homework due 4/14/09 Name ___________________________________ Nestler, E. J. , & R. C. Malenka (March 2004). The addicted brain. Scientific American, 78-85. 1. Describe the general symptoms and personal outcomes that often accompany being addicted to a drug. 2. Do animals like the same drugs that humans do? How do we know this? 3. Describe some of the symptoms seen in animals that have taken drugs of abuse for a prolonged period of time. Are they likely to relapse after a period of non- use? What can help trigger relapse? 4. Why do we think the secretion of dopamine as the basis for reward is evolutionarily ancient? 5. Describe the general function of the following brain structures as they relate to reward in mammals a. Amygdala b. Hippocampus c. Frontal Cortex d. Ventral Tegmental Area/Nucleus Accumbens pathway as “rheostat” 6. How do we know that the above brain areas likely participate similarly in human reward?
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7. What is it that all drugs of abuse have in common? Describe why both cocaine and heroin produce this response.
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